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Tim Ferriss
5:069/15/25

5 Supplements To Slow Aging (Scientist Explains)

TLDR

Five supplements, including creatine, vitamin D, and melatonin, can potentially slow aging and provide neuroprotective benefits, with dosages and necessity varying based on individual factors like diet, health conditions, and lab test results.

Takeways

CoQ10 supports cardiovascular health, with Idebinone as a stabilized form used in protocols like the Deanna protocol for ALS.

Creatine monohydrate benefits include supporting Alzheimer's and recovery from sleep deprivation, using split dosages.

Vitamin D and melatonin are neuroprotective supplements; it's important to monitor vitamin D levels through lab testing.

Certain supplements, such as creatine monohydrate, vitamin D, and melatonin, may offer anti-aging and neuroprotective benefits. Creatine is highlighted for its potential in managing Alzheimer's disease, while vitamin D levels should be carefully monitored through lab tests. Omega-3 supplementation might be necessary for those not consuming enough fish, with brands like Nordic Naturals recommended.

CoQ10 and Idebinone

00:00:05 CoQ10 is beneficial for cardiovascular health, especially for individuals on statins or metformin, which can deplete it; Idebinone is a drug-stabilized form used in the Deanna protocol for ALS. While Idebinone became a standard treatment for Friedrich's ataxia, CoQ10 (specifically Ubiquinol) is a suitable substitute, but high doses showed kidney toxicity in rodent models, indicating caution is needed when using potent forms of CoQ10.

Creatine Monohydrate

00:02:24 Creatine monohydrate has been a staple supplement for a long time, with emerging data suggesting exogenous ketones could be the next big thing; it shows promise in treating Alzheimer's disease, with dosages of 10-20 grams per day potentially beneficial. It can also aid in recovering from sleep deprivation, though split dosing is recommended.

Vitamin D

00:03:06 Vitamin D supplementation is important, but levels should be monitored to stay within 60-80, as levels over 100 are not desirable. Despite living in a sunny climate, supplementation may still be necessary to maintain optimal levels.

Melatonin

00:03:45 Melatonin is a great neuroprotective antioxidant supplement, best taken at nighttime.

Omega-3

00:03:51 Omega-3 supplementation may not be necessary for everyone, as sufficient levels can be achieved through diet, especially with foods like sardines; for those who don't consume enough fish, Nordic Naturals is a recommended brand. Omega-3 levels, specifically EPA and DHA, are likely to become a standard part of blood work in the future due to the growing body of data supporting their importance.